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Um and Tissue Samples for Patient's with Biopsy Proven or Suspected Malignant Disease. Immediately after surgical resection tissues were snap frozen and kept at -80 until RNA isolation. For RT-PCR assessment of TUSC2 expression we used tumor/control matched specimens derived from thirty MPM patients. Control specimens were derived from unaffected peritoneum. RNA from these specimens was extracte
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Inding property for TUSC2. N-terminus of TUSC2 shows 40 identity with the IRF7 segment that contains a DNA-binding site (framed). Histogram shows positions conserved in the IRF protein family. The arginine residue (R) conserved throughout the IRF protein family is marked with asterisk. B. Different mechanisms of TUSC2 down-regulation in tumor and immune cells. Modulation of TUSC2 in tumor and h
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