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Alloimmune haemolytic anaemia or haemolytic disease of the newborn (HDN) occurs due to transplacental passage of clinically relevant IgG maternal allo-antibodies which react with antigens expressed on fetal red blood cells. The most common allo-antibodies causing severe haemolytic disease are anti-D, anti-c, and anti-K1. Exchange transfusion is indicated for severe hyperbilirubinaemia (despite ph
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